As researchers learn more about Alzheimer’s disease, one thing is clear: The plaques that build up in the brain and cause symptoms of dementia are strongly connected with low thiamine levels. In fact, in an animal study, Cornell researchers found that thiamine deficiency reduces protective activity in the brain by 80%. By the time folks notice memory loss, they are likely already low in thiamine. That’s why I recommend taking 300 mg. of benfotiamine daily.